Fig. 2. Multiple myeloma produces high levels of IL-10.

A Cytokine screening of the BM supernatant of MM-bearing vs naïve mice. Cytokine levels in BM supernatants of naïve (n = 5) and MM-inoculated (n = 5) KaLwRij immunocompetent mice was measured by Luminex. Cytokine levels MM bearing mice are represented as fold-change of naïve mice. B Levels of IL-10 in the BM supernatant of MM-bearing vs naïve mice. IL-10 levels in BM supernatants of naïve (n = 5) and MM-inoculated (n = 5) KaLwRij immunocompetent mice was measured by Luminex. IL-10 levels we presented as pg/ml. C IL-10 concentrations in BM supernatants of healthy donors (n = 3) and MM patients (n = 10), measured using enzyme-linked immunosorbent assay (ELISA) and presented as pg/ml. (Bars: Average ± SEM, *p < 0.05).