Fig. 7. Transcriptomic changes in the nasal mucosa do not reflect ongoing inflammation in the distal lung in patients with RPRA.
a, UMAP plot showing integrated scRNA-seq analysis of nasal mucosa from patients with RPRA (n = 5) and healthy controls (n = 6). b, UMAP from a split by patients with RPRA or healthy controls. c, UMAP from a showing individual patients with RPRA (RPRA02, RPRA03 and RPRA05–RPRA07, n = 5) and healthy volunteers (HV11–HV13, HV15–HV17, n = 6). d, Relative cell-type abundance of cell clusters as in a in patients with RPRA (n = 5) and healthy controls (n = 6). No differences are significant (q < 0.05, pairwise Wilcoxon’s rank-sum tests with FDR correction).