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. 2024 Oct 29;15:9306. doi: 10.1038/s41467-024-53778-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, c Left: overview of the type IV-A1 (a) and type IV-A3 effectors (c). Cas proteins are shown as translucent cartoons. Right: close-up view on the seed region in TS position −1 to −5 in types IV-A1 (a) and IV-A3 (c). Notch motif side chains in proximity to the base pair in position −1 are shown as sticks. b, d Cas7.3 (purple) of types IV-A1 (b) and IV-A3 (d) associated with the TS (blue) and crRNA (orange) hybrid in two 90° rotated views. The right panels show the adjacent Cas7 subunits (transparent cartoon).