Table 5.
Simple Cox survival analysis—First onset composite event.
| First onset composite event | |||||
|---|---|---|---|---|---|
| Comorbidities | B | p-value | HR | 95% CI | |
| Lower | Upper | ||||
| Age year | 0.01 | 0.52 | 1.01 | 0.98 | 1.05 |
| Gender men | − 0.64 | 0.14 | 0.53 | 0.22 | 1.24 |
| Body mass index kg/m2 | 0.11 | 0.02 | 1.12 | 1.02 | 1.23 |
| Diabetes Mellitus | 0.42 | 0.34 | 1.52 | 0.65 | 3.58 |
| Hypertension | 0.48 | 0.33 | 1.61 | 0.61 | 4.25 |
| Current smoker | − 0.20 | 0.69 | 0.81 | 0.29 | 2.22 |
| Dyslipidemia | 0.17 | 0.67 | 1.22 | 0.49 | 3.03 |
| Previous cardiovascular disease | |||||
| Coronary artery disease | 1.57 | 0.002 | 4.8 | 1.79 | 12.84 |
| Cerebrovascular diseases | 0.84 | 0.23 | 2.32 | 0.58 | 9.22 |
| Chronic Kidney Disease | 1.27 | 0.01 | 3.55 | 1.32 | 9.45 |
| Heart Failure variables | |||||
| “De novo” Heart Failure | 1.46 | 0.009 | 0.2 | 0.07 | 0.068 |
| Duration of Heart Failure | 0.59 | 0.02 | 1.8 | 1.09 | 2.99 |
| Previous treatments | |||||
| Aspirin | 0.76 | 0.08 | 2.14 | 0.91 | 5.05 |
| BB | 0.42 | 0.34 | 1.52 | 0.65 | 3.58 |
| Furosemide | 1.86 | < 0.001 | 6.41 | 2.53 | 16.25 |
| Statins | 1.17 | 0.01 | 3.24 | 1.30 | 8.05 |
| Aldactone | − 0.08 | 0.92 | 0.92 | 0.19 | 4.4 |
| Eplerenone | 2.56 | 0.02 | 12.92 | 1.62 | 103.31 |
| Laboratory values | |||||
| Hematocrit | − 0.07 | 0.09 | 0.93 | 0.86 | 1.01 |
| Hemoglobin | − 0.18 | 0.09 | 0.83 | 0.67 | 1.03 |
| HbA1c | 0.21 | 0.15 | 1.24 | 0.92 | 1.66 |
| Uric Acid | 0.19 | 0.06 | 1.21 | 0.99 | 1.47 |
| Creatinine | 1.17 | 0.02 | 3.23 | 1.23 | 8.46 |
| mGFR | − 0.02 | 0.06 | 0.98 | 0.97 | 1.00 |
| eGFR MDRD | − 0.01 | 0.1 | 0.99 | 0.97 | 1.00 |
| eGFR CKD_EPI | − 0.01 | 0.19 | 0.99 | 0.98 | 1.00 |
| Cystatin | 0.31 | 0.45 | 1.36 | 0.60 | 3.08 |
| eGFR CKD_EPI_cys | − 0.003 | 0.76 | 0.99 | 0.98 | 1.01 |
| eGFR CKD_EPI_Cr_cys | − 0.006 | 0.54 | 0.99 | 0.98 | 1.01 |
| BUN/Cr ratio | − 0.016 | 0.20 | 0.9 | 0.95 | 1.01 |
| Troponin T us | 0.001 | 0.25 | 1.001 | 0.99 | 1.00 |
| BUN | 0.02 | 0.18 | 1.02 | 0.99 | 1.04 |
| Total Cholesterol | − 0.02 | 0.001 | 0.98 | 0.97 | 0.99 |
| Triglycerides | − 0.001 | 0.76 | 0.99 | 0.99 | 1.01 |
| LDL | − 0.03 | 0.01 | 0.97 | 0.95 | 0.98 |
| HDL | − 0.006 | 0.69 | 0.99 | 0.97 | 1.02 |
| logNT-proBNP | − 0.32 | 0.57 | 0.72 | 0.24 | 2.2 |
| HR | − 0.03 | 0.004 | 0.97 | 0.98 | 0.99 |
| Systolic blood pressure | − 0.01 | 0.06 | 0.98 | 0.97 | 1 |
| Diastolic blood pressure | − 0.02 | 0.07 | 0.98 | 0.95 | 1 |
| Atrial Fibrillation | − 0.19 | 0.67 | 0.82 | 0.34 | 1.98 |
| LV end-diastolic diameter | 0.07 | 0.02 | 1.07 | 1.01 | 1.1 |
| E/é ratio | − 0.02 | 0.54 | 0.98 | 0.92 | 1.04 |
| LVOT-VTI | − 0.005 | 0.90 | 0.99 | 0.91 | 1.09 |
| Left ventricular ejection fraction (LVEF) | − 0.03 | 0.048 | 0.97 | 0.94 | 0.99 |
Univariable regression analysis. variables associated with the first onset of a composite event.
LVOT—VTI, left ventricular outflow tract volume-time interval; CKD, chronic kidney disease.