TABLE 2.
Demographic and clinical characteristics of the patients with positive cultures for C. parapsilosis in the NICU from September 2000 to December 2001
| Variable | Patients with BSIs (cases; n = 10)a | Patients without BSIs (noncases; n = 39)a
|
P valueb | |
|---|---|---|---|---|
| Patients with superficial infections (n = 15) | Patients with colonization (n = 24) | |||
| Baseline characteristics | ||||
| Birth weight (g [range]) | 665 (480-830) | 810 (360-1,200) | 895 (440-1,410) | <0.01 |
| Gestational age (wk [range]) | 25 (24-27) | 27 (25-29) | 27 (23-32) | <0.001 |
| Male sex (no. [%] of patients) | 7 (70) | 8 (53) | 15 (63) | 0.72 |
| Antenatal antibiotics (no. [%] of patients) | 5 (50) | 5 (33) | 8 (33) | 0.46 |
| Vaginal delivery (no. [%] of patients) | 5 (50) | 5 (33) | 8 (33) | 0.46 |
| Apgar score (range) at 5 min of age | 6 (3-8) | 7 (2-10) | 7 (3-9) | 0.20 |
| Factors associated with hospitalization | ||||
| Length of stay in the NICU (days [range]) | ||||
| Total | 86 (16-111) | 58 (3-110) | 42 (10-87) | <0.01 |
| Before first CP isolationc | 13 (9-33) | 17 (4-45) | 14 (4-36) | 0.8 |
| Duration of mechanical ventilation (days [range]) | ||||
| Total | 48 (15-68) | 12 (3-29) | 14.5 (1-38) | <0.001 |
| Before first CP isolationc | 13 (9-33) | 11 (3-28) | 10.5 (1-33) | 0.09 |
| Duration of PNd (days [range]) | 13 (9-33) | 16 (3-23) | 14 (4-30) | 0.5 |
| Duration (days [range]) of vascular accessd | ||||
| Umbilical catheter | 4 (0-14) | 0 (0-5) | 0 (0-7) | <0.01 |
| Arterial catheter | 12.5 (6-17) | 11 (0-17) | 10 (3-16) | 0.10 |
| Central venous catheter | 9 (4-20) | 10 (0-17) | 6.5 (0-15) | 0.15 |
| Treatment with antibioticsd (no. [%] of patients) | ||||
| Ampicillin-netilmicin | 10 (100) | 14 (97) | 24 (100) | 1.0 |
| Vancomycin and/or cephalosporins | 10 (100) | 13 (87) | 22 (92) | 0.57 |
| Fluconazole | 5 (50) | 4 (27) | 9 (38) | 0.48 |
| Amphotericin B | 1 (10) | 0 (0) | 1 (4) | 1.0 |
| Surgical proceduresd (no. [%] of patients) | 5 (50) | 2 (13) | 8 (33) | 0.25 |
| Mortalitye (no. [%] of patients) | 1 (10) | 0 (0) | 3 (13) | 1.0 |
a
Data on continuous variables are presented as medians (ranges).
b
Cases versus noncases, i.e., patients with BSI versus patients without BSIs.
c
From blood cultures (cases) or other cultures (noncases). CP, Candida parapsilosis.
d
Before first positive blood cultures (cases) or other cultures (noncases). PN, parenteral nutrition with lipids.
e
Within 7 days after a positive culture for C. parapsilosis.