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. 2024 Oct 28;15(10):782. doi: 10.1038/s41419-024-07152-0

Fig. 2. Multipanel figure depicting the levels of ferroptosis-related proteins at different stages of AD pathology.

Fig. 2

a Investigated groups, b order of stainings in OC (BA17) and quantification and example images of ferroptosis-related proteins in WM and GM in control and diseased subjects (c–h). No changes in ferritin protein (c) and 4-HNE (f) in any of the groups were observed. Higher expression of ferroportin (d), NCOA4 (e), GPX4 (g) and cytochrome c (h) was observed in GM compared to WM. Both NCOA4 and GPX4 protein expression in GM significantly decreases with increasing severity of AD pathology (NCOA4 control vs AD3, p = 0.0424; GPX4 control vs AD2, p = 0.0352 and GPX4 control vs AD3, p = 0.0476). In WM, a similar trend can be observed although not significant. Each dot on the graph stands for the average of three annotated areas per subject. One colour per subject is consistent across all graphs. Ordinary one-way ANOVA was used to determine significance between groups (p < 0.05).