. 2023 Nov 9;12:1452. [Version 1] doi: 10.12688/f1000research.131508.1

Table 3. Key and allosteric binding residues of the binding pocket.

Protein name	Key binding residues	Allosteric binding residues	Reference
SARS-CoV-2 S glycoprotein (spike protein)	Lys417, Gly446, Leu455, Tyr449, Tyr453, Phe456, Phe486, Asn487, Tyr489, Gln493, Gly496, Gln498, Thr500, Asn501, Gly502, Tyr505	Gly488 Gly502 Asp427 Asp428 Lys986 Lys386 Leu387 Asp614	⁶ ^, ²⁷ ^, ²⁸
Angiotensin converting enzyme-2 (binding interface)	Gln24, Thr27, Phe28, Asp30, Lys31, His34, Glu35, Glu37, Asp38, Tyr41, Gln42, Leu79, Met82, Tyr83, Asn330, Lys353, Gly354, Asp355, Arg357, Arg393		⁶ ^, ²⁷