Table sd1. Ligand libraries used in the study.

Library	Number of compounds	Database	Description	Source: available for download from the following online databases
Natural products with experimentally verified in vivo activity	1,500	Zinc	SDF files of approved natural products with in vivo efficacy	http://blaster.docking.org/zinc/. (RRID:SCR_002700)
Food and Drug Administration (FDA) approved medications	1,100	DrugBank	SDF files of FDA approved drugs	http://www.drugbank.ca/. (RRID:SCR_002700)
FDA approved medications	1,614	Zinc	SDF files of FDA approved drugs	http://blaster.docking.org/zinc/. (RRID:SCR_002700)
Worldwide (not FDA) approved medications	3,440	DrugBank	SDF files of worldwide approved drugs non-FDA	http://www.drugbank.ca/. (RRID:SCR_002700)
Worldwide (not FDA) approved medications	4,288	Zinc	SDF files of FDA approved drugs	http://blaster.docking.org/zinc/. (RRID:SCR_002700)
Naturaceuticals	74	DrugBank	SDF files of approved natraceutics	http://www.drugbank.ca/. (RRID:SCR_002700)
Final Comprehensive library compiled composed of all compounds listed above, redundant structures were excluded	7,476	DrugBank and Zinc	SDF files of all FDA and worldwide approved medications and natural products in addition to natural products with verified physiological activity	http://www.drugbank.ca/. (RRID:SCR_002700) http://blaster.docking.org/zinc/. (RRID:SCR_002700)