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. 2024 Oct 28;10:454. doi: 10.1038/s41420-024-02220-y

Fig. 7. Xanthohumol inhibits in vivo tumor growth in osimertinib-resistant cells.

Fig. 7

The xenograft tumor model analyzed the effect of xanthohumol administration concentration (Low: 10 mg/kg/2 days; High: 30 mg/kg/2 days) on HCC827OR tumor volume (A), tumor mass (B) and tumor weight (C). **p < 0.01.***p < 0.001. Xenograft tumor model analyzing the effect of xanthohumol administration concentration on H1975OR tumor volume (D), tumor mass (E) and tumor weight (F). **p < 0.01.***p < 0.001. G IHC method to analyze the effect of xanthohumol administration concentration on the expression levels of Ki67 and c-Met in HCC827OR tumor tissues. IHC images are shown on the left, and statistical analysis is shown on the right. Scale bar, 25 μm. ***p < 0.001. H Changes in body weight of HCC827OR transplanted tumor-bearing mice treated with control or different concentrations of xanthohumol administration. ns indicates no statistical significance. I WBC, RBC, Hb, AST, ALT, and BUN in blood samples of HCC827OR transplanted tumor-bearing mice treated with control or different concentrations of xanthohumol administration were analyzed. ns indicates no statistical significance.