Table 1.

Recent TurboID-based organelle proteome studies

	Target organelle	Reference	TurboID construct	Main finding
Single organelle	Lysosome	Shin et al. [12]	LYCHOS-TurboID (LYCHOS-TiD)	Binding between LYCHOS and GATOR1
	Lysosome	Tan et al. [13]	LAMP1-TurboID (Lyso-TurboID)	Accumulation of PI4K2A and ORP upon LMP
	ER	Kim et al. [14]	SEC61B-TurboID (iSLET)	Liver-specific secretory protein labeling
	ER	Wei et al. [15]	TurboID-KDEL (ER-TurboID)	4-cell-type secretomes (hepatocyte, myocyte, pericyte and myeloid cell)
	ER	Wei et al. [19]	FLEx-ER-TurboID	21-cell type secretomes of exercise training in mice
Organelle contact	ER-mitochondria	Kwak et al. [21]	N-BirA-SEC61B (B1-SEC61B) Tom20-BirA-C (TOM20-B2)	Identification of 115 MAM-specific proteins
	ER-mitochondria	Cho et al. [22]	N-TOM20-TurboID (OMM-Tb(N)) TurboID-Cb5-C (Tb(C)-ERM)	Identification of 101 ER-mitochondria contact proteins
	Mitochondria-lysosome	Kim et al. [7]	TOM20-TurboID LAMP1-TurboID TM4SF5-TurboID	Identification of 63 MLCS proteins
	ER-Golgi	Yeerken et al. [23]	SEC31A-TurboID	Regulation of ER-to-Golgi transport via Nlp
	ER-Golgi	Kovács et al. [24]	OSBP-TurboID	Lipid exchange and cargo sorting via OSBP

_{ER, endoplasmic reticulum; LMP, lysosomal membrane permeabilization; MAM, mitochondrial-associated membrane; MLCS, mitochondria-lysosome contact site; Nlp, ninein-like protein; OSBP, oxysterol binding protein.}