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. 2005 Jun;12(6):705–712. doi: 10.1128/CDLI.12.6.705-712.2005

FIG. 3.

FIG. 3.

Cross-linking of inhibitory receptors reduces the frequency of IgG+ and IgE+ B lymphocytes. (A) B lymphocytes were stimulated with CD40L-transfected cells plus IL-4 in the presence (+) of isotype-matched control MAbs or with the cross-linked MAbs specific for the inhibitory receptors. After 6 and 12 days, B lymphocytes were analyzed for the expression of membrane IgM, IgG, and IgE. Data are percentages of IgM+, IgM− IgG+ (IgG+), and IgM− IgE+ (IgE+) cells at the indicated time of culture. Samples that are significantly different (P < 0.05) from the control culture (B cells stimulated with CD40L-transfected cells plus IL-4) are indicated with an asterisk. (B) B lymphocytes were stimulated with LPS plus IL-4 (+) in the presence (+) of MAbs as indicated. After 6 and 12 days, B lymphocytes were analyzed for the expression of membrane IgM, IgG, and IgE. Data represent the percentages of IgM+, IgM− IgG+ (IgG+), and IgM− IgE+ (IgE+) cells at the indicated times of culture. Samples that are significantly different (P < 0.05) from the control culture (B cells treated with LPS plus IL-4) are indicated with an asterisk.