Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Oct 28;15:9282. doi: 10.1038/s41467-024-53395-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a, b Three-dimensional reaction-diffusion simulations with two types of particles, colored red and yellow, that disappear after colliding. Snapshots of cells from the indicated time during simulation are shown at left, and the number of particles remaining over time under different parameter conditions are shown at right. a Effect of varying the size of the polar microdomain while holding the particle diffusion rate at 1/40th the rate in bulk cytoplasm. b Effect of varying particle diffusion rates within polar microdomains while holding polar microdomain size at 0.5% of total cell volume, or of limiting polar concentration to only one reactant (dotted line). c A model of C. crescentus proteolysis that includes low-affinity interactions (black arrows) between substrates (Sub1 and Sub2), adaptors, and ClpXP protease, in which some proteins interact directly with PopZ (red arrows) and become concentrated in polar microdomains. Charts show the fractions of substrate particles remaining in simulations run with or without PopZ, either without (left) or with (right) a direct interaction between Sub1 and PopZ. d Localization of CpdR and associated ClpXP complexes as a consequence of asymmetric CckA signaling activity. Inset panels show fluorescence images of a C. crescentus stalked cell, where mChy-PopZ is localized to both poles and CpdR-YFP is localized to only the stalked pole. Scale bar = 10 μm. Source data are provided as a Source Data file. Graphics: BioRender.