Table 2.

Missense and nonsense protein altering rare variant burden tests predict multiple genes associated with advanced AMD

Gene	Chr.	Variants (N)	Carriers (N)	Freq. Cases	Freq. Controls	OR	P
Missense and/or Nonsense RV burden tests (P  10E-04)
CFI	4	40	218	0.0261	0.0072	4.57	3.13E-14
CFH	1	39	322	0.0269	0.0192	2.05	2.14E-06
SLC16A8	22	25	440	0.0398	0.0240	1.78	1.50E-05
CFHR5	1	26	292	0.0119	0.0265	0.48	5.58E-05
AAED1	9	12	80	0.0084	0.0035	3.28	1.67E-04
RGS7	1	7	44	0.0046	0.0019	4.25	2.87E-04
MAP1S	19	24	511	0.0322	0.0381	0.63	3.12E-04
OSGIN2	8	9	29	0.0020	0.0020	6.02	3.74E-04
Nonsense RV burden tests (P < 10E-04)
SLC16A8	22	5	301	0.0284	0.0156	1.71	6.91E-04
DNAH3	16	26	67	0.0036	0.0054	0.32	8.53E-04