Table 5.

Parameters used for oritavancin PBPK modelling

Model parameter	Value
Drug name	Oritavancin
LogP	3.59
Chem_property	Zwitterion
Pka1	3.36
Pka2	7.76
Protein_binding	90%
Blood_to_plasma_ratio	0.8
Molecular_weight	1793.1
Absorption inputs
Route_of_admin	Intravenous bolus and infusion
Infusion_time	3 h
Clearance inputs
Clearance_type	IV plasma CL
Apparent_cl	6.2
Apparent_cl_units	mL/min
F_value	1.0
Distribution and elimination inputs
Vd_method	Rodgers & Rowland– Schmitt
Renal_cl	0.445 L/h
Dosing inputs
Dose	200; 800; 1200 (mg)
Dose_interval	24; 0; 0 (hours)
Dose_repeats	2; 0; 0
Dose_end_time	48; 0; 0 (hours)
Simulation_time	1440 (hours)
Optional inputs
Population	100
Sex	Both male (50) and female (50)
Age	18–60 (39.0 ± 12.31 years)
Weight	88.1 ± 16.91 kg