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. 2024 Oct 23;19:393. doi: 10.1186/s13023-024-03364-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — PRISMA 2020 flow diagram including searches of databases, registers and other sources. ^a Duplicates identified in phase 2 were either missed by de-duping tools or were clinical trial registration entries pertaining to published clinical trials included in the review. ^bDiscussions with clinician scientists regarding rare subtypes not already captured in the review revealed three potentially relevant reports. Since these reports did not meet eligibility criteria and did not include any new potentially relevant outcomes, they were not included in the review. From: Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372: n71. https://doi.org/10.1136/bmj.n71. For more information, visit: http://www.prisma-statement.org/