Table 4.

Independent Predictors of Impaired Cardiorespiratory Fitness Among Childhood Cancer Survivors

	Adjusted OR (95% CI) for Vo2 <80% Predicted	P Value
Age at evaluation	0.98 (0.96-0.99)	0.043
≥2 measures of autonomic dysfunction	2.71 (1.82-4.02)	<0.001
Female	0.59 (0.43-0.80)	<0.001
MVPA ≥150 min/wk	0.49 (0.36-0.67)	<0.001
Quadriceps strength, 1 SD decrease	1.56 (1.34-1.81)	<0.001
FEV1 < 80%	3.24 (2.27-4.64)	<0.001

Other variables included in this multivariable model, but not identified as independent predictors, were: age at diagnosis, body mass index, smoking history, antihypertensive at the time of cardiopulmonary exercise test, modified total neuropathy score (MTNS) ≥ 5, global longitudinal strain ≥1.5 SD, and left ventricular ejection fraction. Note that body mass index was included in the model as a 3-category variable.

FEV₁ = forced expiratory volume in 1 minute; MVPA = moderate or vigorous physical activity; Vo₂ = oxygen consumption.