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. 2024 Aug 27;6(5):684–696. doi: 10.1016/j.jaccao.2024.07.010

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Central Illustration — Does Enalapril Prevent Cardiotoxicity When Given Before and During High-Dose Anthracycline Chemotherapy?

The PROACT (Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma) trial did not find evidence supporting the use of enalapril to prevent cardiotoxicity in patients receiving high-dose anthracycline chemotherapy for breast cancer or non-Hodgkin lymphoma. cTnI = cardiac troponin I; cTnT = cardiac troponin T; GLS = left ventricular global longitudinal strain; LVEF = left ventricular ejection fraction; RCT = randomized controlled trial.