Table 3.

The Childhood Cancer Risk among Offspring of Mothers with Hypertension before Birth, Stratifying by Medication Use

	Hypertension before birth (all types)
	Cases (n=2,780)	Non-cases (n=2,291,512)	Crude HR (95% CI)	*Adjusted HR (95% CI)
No diagnosis of hypertension before birth	2,664	2,194,495	1 (ref)	1 (ref)
Maternal hypertension before birth	92	72,656	1.14 (0.93–1.40)	1.12 (0.90–1.41)
No medications before birth	12	11,403	0.94 (0.53–1.65)	0.98 (0.56–1.73)
Any medications before birth other than diuretics	54	40,583	1.20 (0.92–1.57)	1.15 (0.86–1.54)
Diuretics before birth	26	20,670	1.13 (0.77–1.66)	1.16 (0.77–1.74)
Hypertension and diuretic use between conception (0 weeks) and birth	10	8,945	0.98 (0.53–1.83)	0.94 (0.48–1.83)
Hypertension but without diuretic use between conception (0 weeks) and birth	80	63,350	1.13 (0.91–1.42)	1.13 (0.89–1.43)

^*Model adjusted for parity, preeclampsia/eclampsia in the index pregnancy, family income, infections in pregnancy, and hyperthyroidism