Fig. 2.

Metabolites associated with the asymptomatic infection of SARS-COV-2. (A) The OPLS-DA scores plot of AS vs. HC. The Y axis represents orthogonal T score, and the X axis represents T score; (B) The volcano plot of AS vs. HC. Red dots represent the up-regulated metabolites(log₂FC ≥ 1, VIP ≥ 1); blue dots represent the down-regulated metabolites (log₂FC≤-1, VIP ≥ 1); gray dots represent metabolites without significant changes (-1 < log₂FC < 1, VIP ≤ 1). (C) The KEGG analysis of the DEMs and in AS vs. HC. (D) The important metabolites prioritized by xgboost analysis. (E) Receiver operating characteristic (ROC) and performance of the xgboost model in the test sets. (F) The heatmap of 41 metabolites in AS vs. HC. (G) The correlation heatmap of DEMs. (H) the raw intensity of Adenosine 5’-Monophosphate (AMP), deoxyguanosine 5’-monophosphate (dGMP), 3’-Aenylic Acid and Hypoxanthine