Fig. 5.

Metabolites associated with the viral persistence of SARS-CoV-2 infection. (A) The OPLS-DA scores plot of LTNP vs. STNP. The Y axis represents orthogonal T score, and the X axis represents T score; (B) The volcano plot of LTNP vs. STNP. Red dots represent the up-regulated metabolites (log₂FC ≥ 0.58, VIP ≥ 1); blue dots represent the down-regulated metabolites (log₂FC≤-0.58, VIP ≥ 1); gray dots represent metabolites without significant changes (-0.58 < log₂FC < 0.58, VIP ≤ 1). (C) The KEGG analysis of the DEMs in LTNP vs. STNP. (D) The important metabolites prioritized by xgboost analysis. (E) Receiver operating characteristic (ROC) and performance of the xgboost model in the test sets. (F) The heatmap of 14 metabolites in LTNP vs. STNP. (G) The correlation heatmap of DEMs. (H) the raw intensity of Shikimic Acid, Glycyrrhetinic acid and 3-Hydroxybutyrate