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. 2016 Jul 7;58(7):600–608. doi: 10.1111/dgd.12301

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© 2016 The Authors Development, Growth & Differentiation published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Developmental Biologists.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Histological analysis of testes and epididymides of the Zfp318 ^−/− mouse. PAS‐hematoxylin‐stained sections of testes (A‐D) and caput epididymides (E and F). Depicted areas in A–D are enlarged in a–d, respectively. Roman numerals in A and C show the stage of the cycle of the mouse seminiferous epithelium. Seminiferous tubules in B and D were regarded as the corresponding stage of A and C, respectively. The wild‐type male shows normal testicular morphology (A and C), whereas the mutant testis shows affected spermatogenesis including vacuole formation (B, asterisk) and sparsely located elongated spermatids (D). Note the cells with the large nuclei (b and d, arrowheads) among the normal round spermatids (arrows), comparable to those of pachytene spermatocytes (b and d, white arrowheads). Accumulation of the sperm is seen in the lumen of the wild‐type epididymal duct (E). Sloughed germ cells with few sperm are observed in the mutant (F). Bars: 50 μm.