Skip to main content
. 2015 Dec 15;58(1):94–105. doi: 10.1111/dgd.12248

Figure 1.

Figure 1

Overview of the ecdysteroid biosynthesis pathway and the regulatory mechanisms through transcriptional network in the prothoracic gland (PG) of Drosophila melanogaster. Several distinct signaling pathways regulate ecdysteroid biosynthesis and some pathways potentially target transcription factors (TFs) to regulate ecdysteroidogenic enzyme gene expressions. The ecdysteroid biosynthesis pathway is colored in blue. It starts with dietary cholesterol. Ecdysteroid biosynthesis enzymes are highlighted in green. Hexagons represent ecdysteroidogenic TFs that are listed in Table 1. Among them, nuclear receptors are colored in sky blue. In each signaling pathway, only the key components are depicted. Yellow “P” means phosphorylation. DILPS, Drosophila insulin‐like peptides; ERK, Extracellular signal‐regulated kinase; InR, Insulin receptor; NO, nitric oxide; PI3K, Phosphoinositide 3‐kinase; PG, prothoracic gland; PTTH, Prothoracicotropic hormone; TOR, Target of rapamycin.