Table. Characteristics of 45 extrapulmonary Mycobacterium abscessus infections, France, 2012–2020*.
| Variable |
Infections |
Total |
||
|---|---|---|---|---|
| Bone/joint |
Skin/soft tissue |
Lymph node |
||
| Patients, no. (%) | 14 (30) | 10 (22) | 8 (18) | 45 (100) |
| Mean age, y, ± SD | 50.2 ± 26.6 | 60.8 ± 21.2 | 43.7 ± 25.3 | 51.4 ± 24.5 |
| M/F sex ratio |
1.33 |
0.66 |
1 |
0.88 |
| Geographic origin, no. (%) | ||||
| Metropolitan France | 3 | 4 | 2 | 13 (29) |
| Overseas French territories | 4 | 3 | 2 | 13 (29) |
| Foreign countries |
7 |
3 |
4 |
19 (42) |
| Underlying immune disorder, no. (%) | ||||
| No known immunodeficiency | 13 | 4 | 5 | 28 (62) |
| Immunosuppressive treatment | 1 | 5 | 2 | 9 (20) |
| Solid tumor | 0 | 0 | 1 | 4 (9) |
| Malignant hemopathy |
0 |
1 |
0 |
2 (4) |
| Clinical features, no. (%) | ||||
| B symptoms† | 7 | 4 | 2 | 17 (38) |
| Skin involvement |
4 |
10 |
2 |
22 (49) |
| Initial injury | 12 | 3 | 3 | 27 (60) |
| Median months to diagnosis [range] | 4.5 [0.25–72] | 1.5 [1–72] | 1 [0.25–3] | 3 [0.25–72] |
| Environmental | 4 | 1 | 2 | 7 (16) |
| Healthcare associated |
8 |
2 |
1 |
20 (44) |
| M. abscessus subspecies and erm(41) sequevars, no. (%) | ||||
| abscessus T28 | 7 | 5 | 1 | 19 (40) |
| abscessus C28 | 2 | 1 | 0 | 6 (13) |
| bolletii | 2 | 2 | 4 | 12 (26) |
|
massiliense
|
3 |
2 |
2 |
9 (19) |
| Medical management, no. (%) | ||||
| Surgery + antimicrobial regimen | 11 | 3 | 3 | 22 (49) |
| Surgery alone | 1 | 0 | 1 | 3 (7) |
| Antimicrobial regimen alone | 2 | 6 | 3 | 13 (29) |
| Media months of antimicrobial regimen duration [range] |
6 [2–12] |
6 [3–15] |
6 [1–6] |
6 [1–long-term] |
| Outcome, no. (%) | ||||
| Cure | 13 | 7 | 7 | 33 (73) |
| Relapse then cured | 0 | 0 | 0 | 3 (7) |
| Not available for follow-up | 1 | 2 | 1 | 5 (11) |
| Death | 0 | 1 | 0 | 4 (9) |
*Values are no. (%) except as indicated. †Fever, night sweats, or weight loss.