Comparison 2. Subgroup analysis: type of drug.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amphetamine use (UA)	7		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 Bupropion	2	103	Mean Difference (IV, Random, 95% CI)	‐1.52 [‐4.20, 1.17]
1.2 Dexamphetamine	1	60	Mean Difference (IV, Random, 95% CI)	‐0.30 [‐2.66, 2.06]
1.3 Methylphenidate	1	24	Mean Difference (IV, Random, 95% CI)	1.5 [‐4.24, 7.24]
1.4 Modafinil	3	286	Mean Difference (IV, Random, 95% CI)	‐0.21 [‐0.84, 0.42]
2 Amphetamine use (hair analysis)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Dexamphetamine	1	22	Mean Difference (IV, Random, 95% CI)	0.53 [‐6.02, 7.08]
3 Sustained abstinence	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Bupropion	3	254	Risk Ratio (M‐H, Random, 95% CI)	1.36 [0.87, 2.14]
3.2 Modafinil	2	281	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.64, 1.83]
3.3 Methylphenidate	1	24	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.53, 1.49]
4 Self‐reported amphetamine use	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Methylphenidate	1	24	Mean Difference (IV, Random, 95% CI)	0.5 [‐4.76, 5.76]
4.2 Modafinil	1	80	Mean Difference (IV, Random, 95% CI)	‐4.40 [‐8.44, ‐0.36]
4.3 Dexamphetamine	1	29	Mean Difference (IV, Random, 95% CI)	7.71 [‐5.10, 20.52]
5 Retention in treatment	11		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Bupropion	3	254	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.81, 1.18]
5.2 Dexamphetamine	2	109	Risk Ratio (M‐H, Random, 95% CI)	1.42 [0.61, 3.29]
5.3 Methylphenidate	2	58	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.42, 1.94]
5.4 Modafinil	4	370	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.79, 1.26]
6 Amphetamine craving	2		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Bupropion	1	73	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.65, 0.27]
6.2 Modafinil	1	71	Std. Mean Difference (IV, Random, 95% CI)	0.34 [‐0.13, 0.80]
7 Dropouts due to any adverse event	10		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
7.1 Bupropion	2	103	Risk Difference (M‐H, Random, 95% CI)	0.00 [‐0.07, 0.07]
7.2 Dexamphetamine	2	109	Risk Difference (M‐H, Random, 95% CI)	‐0.01 [‐0.12, 0.10]
7.3 Methylphenidate	2	58	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.08, 0.11]
7.4 Modafinil	4	370	Risk Difference (M‐H, Random, 95% CI)	0.01 [‐0.04, 0.07]
8 Dropouts due to cardiovascular adverse events	8		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
8.1 Bupropion	2	103	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.04, 0.09]
8.2 Dexamphetamine	1	49	Risk Difference (M‐H, Random, 95% CI)	‐0.04 [‐0.14, 0.07]
8.3 Methylphenidate	2	58	Risk Difference (M‐H, Random, 95% CI)	0.0 [‐0.09, 0.09]
8.4 Modafinil	3	160	Risk Difference (M‐H, Random, 95% CI)	0.01 [‐0.04, 0.05]
9 Dropouts due to psychiatric adverse events	7		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
9.1 Bupropion	2	103	Risk Difference (M‐H, Random, 95% CI)	‐0.02 [‐0.09, 0.04]
9.2 Dexamphetamine	1	49	Risk Difference (M‐H, Random, 95% CI)	‐0.04 [‐0.14, 0.07]
9.3 Methylphenidate	2	58	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.08, 0.11]
9.4 Modafinil	2	80	Risk Difference (M‐H, Random, 95% CI)	‐0.03 [‐0.10, 0.05]