Comparison 3. Subgroup analysis: type of dependence.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amphetamine use (UA)	7		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 Amphetamine dependence	1	24	Mean Difference (IV, Random, 95% CI)	1.5 [‐4.24, 7.24]
1.2 Methamphetamine dependence	6	449	Mean Difference (IV, Random, 95% CI)	‐0.28 [‐0.87, 0.31]
2 Amphetamine use (hair analysis)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Amphetamine dependence	0	0	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Methamphetamine dependence	1	22	Mean Difference (IV, Random, 95% CI)	0.53 [‐6.02, 7.08]
3 Sustained abstinence	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Amphetamine dependence	1	24	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.53, 1.49]
3.2 Methamphetamine dependence	5	535	Risk Ratio (M‐H, Random, 95% CI)	1.24 [0.88, 1.74]
4 Self‐reported amphetamine use	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Amphetamine dependence	1	24	Mean Difference (IV, Random, 95% CI)	0.5 [‐4.76, 5.76]
4.2 Methamphetamine dependence	2	109	Mean Difference (IV, Random, 95% CI)	0.07 [‐11.39, 11.52]
5 Retention in treatment	11		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Amphetamine dependence	2	58	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.42, 1.94]
5.2 Methamphetamine dependence	9	733	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.91, 1.16]
6 Amphetamine craving	2		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Amphetamine dependence	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
6.2 Methamphetamine dependence	2	144	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.44, 0.59]
7 Dropouts due to any adverse event	10		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
7.1 Amphetamine dependence	2	58	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.08, 0.11]
7.2 Methamphetamine dependence	8	582	Risk Difference (M‐H, Random, 95% CI)	0.00 [‐0.03, 0.04]
8 Dropouts due to cardiovascular adverse events	8		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
8.1 Amphetamine dependence	2	58	Risk Difference (M‐H, Random, 95% CI)	0.0 [‐0.09, 0.09]
8.2 Methamphetamine dependence	6	312	Risk Difference (M‐H, Random, 95% CI)	0.01 [‐0.03, 0.04]
9 Dropouts due to psychiatric adverse events	7		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
9.1 Amphetamine dependence	7	290	Risk Difference (M‐H, Random, 95% CI)	‐0.02 [‐0.06, 0.02]
9.2 Methamphetamine dependence	5	232	Risk Difference (M‐H, Random, 95% CI)	‐0.03 [‐0.07, 0.02]