FIGURE 5.

Effects of different OAHT formulations on serum IL‐β (A), IL‐6 (B), TNF‐α (C), COMP (D), and CRP (E) levels in rats with monosodium iodoacetate (MIA)‐induced OA. The bars and error lines point out the mean and standard deviation. ANOVA and Tukey's post hoc test were performed for statistical comparison. Different letters (a, b, and c) above the bars indicate statistical differences among the study groups (p < .05). IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; TNF‐ α, tumor necrosis factor α; COMP, cartilage oligomeric matrix protein; CRP, C‐reactive protein. F1: Curcuminoids+Gingerols+ acetyl‐11‐keto‐β boswellic acid (AKBA); F2: Curcuminoids+Withania Glycosides+ AKBA; F3: Curcuminoids+Total Withanolides+AKBA; F4:Curcuminoids+AKBA; UCII: Undenatured type II collagen; G + CHON: Glucosamine Hydrochloride, Chondroitin Sulfate, Hyaluronic Acid, Calcium Fructoborate.