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. 2024 Oct 16;11:1491971. doi: 10.3389/fcvm.2024.1491971

Figure 1.

Figure 1

Post-PNX regenerative lung growth is inhibited in the Lepob/ob mouse lungs. (A) Graph showing the ratio of the weight of right lung lobe to mouse body length in C57BL6 (WT), Lepob/+ or Lepob/ob mice 7 days after PNX (n = 8–9, mean ± s.e.m., *p < 0.05). (B) Immunofluorescence (IF) micrographs showing ERG-positive ECs (top), VEGF expression, AQP5-positive alveolar epithelial cells and DAPI (middle) and CD31-positive blood vessels and VEGFR2 expression and DAPI (bottom) in the C57BL6 (WT), Lepob/+ or Lepob/ob mouse lungs 7 days after PNX. Scale bar, 50 μm. (C) Graphs showing the quantification of ERG-positive ECs (left), VEGF (middle) and VEGFR2 (right) expression in the C57BL6 (WT), Lepob/+ or Lepob/ob mouse lungs 7 days after PNX (n = 6–7, mean ± s.e.m., *p < 0.05). (D) Graphs showing the VEGF protein levels in the C57BL6 (WT), Lepob/+ or Lepob/ob mouse lungs (left) and serum (right) 7 days after PNX (n = 5–8, mean ± s.e.m., *p < 0.05).