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Schematic illustration of the angiogenic signaling pathway in lean vs. obese lungs. Schematic illustration showing that angiogenesis and regenerative lung growth after unilateral PNX mediated by adiponectin-TWIST1-VEGF/VEGFR2 signaling are inhibited in Lepob/ob obese mice; post-PNX increases in the levels of adiponectin, TWIST1, VEGF, and VEGFR2 are suppressed in Lepob/ob obese mice.
