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. 2024 Oct 16;15:1411168. doi: 10.3389/fphar.2024.1411168

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Copyright © 2024 Alizadeh, Pourfallah-Taft, Khoshnazar, Safdari, Komari, Zanganeh, Sami, Valizadeh, Faridzadeh, Alijanzadeh, Mazhari, Khademi, Kheirandish and Naziri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Mechanistic Effect of Rutin, Quercetin, Cyanidin, Morin, Philoridzin, Malvidine, Myricetin, and Kaempferol on Depression. Rutin and quercetin can increase serotonin (5-HT). However, cyanidin and quercetin decrease monoamine oxidase (MAO). Rutin and quercetin can raise norepinephrine. Moreover, morin and quercetin can reduce pro-inflammatory cytokines secretion. Philoridzin, and cyanidin have positive effects on tropomyosin receptor kinase B (TrkB). kaempferol has a promising impact on protein kinase B (AKT), which can regulate BDNF translocation. Also, myricetin, and quercetin positively impact BDNF translocation. Finally, philoridzin, cyanidin, malvidine, myricetin, and quercetin have antioxidant effects.