Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Oct 16;15:1411168. doi: 10.3389/fphar.2024.1411168

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Alizadeh, Pourfallah-Taft, Khoshnazar, Safdari, Komari, Zanganeh, Sami, Valizadeh, Faridzadeh, Alijanzadeh, Mazhari, Khademi, Kheirandish and Naziri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The Mechanistics Effect of Apigenin, Biacalein, Genistein, Hesperidin, and Narnigenin. Genistein, baicalein, hesperidin, and naringenin can increase serotonin (5-HT). Also, apigenin and biacalein can elevate dopamine. However, genistein can decrease monoamine oxidase. Moreover, apigenin also can reduce pro-inflammatory cytokines secretion. Apigenin and naringenin can raise norepinephrine. Furthermore, Hesperidin positively affects TrkB. Apigenin has a promising impact on mTOR, which can regulate BDNF translocation. Hesperidin has adverse effects on NF-kB. Baicalein, naringenin, and hesperidin have positive effects on BDNF translocation. Finally, apigenin, baicalein, and naringenin have antioxidant effects.