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. 2024 Oct 16;15:1465226. doi: 10.3389/fneur.2024.1465226

Table 1.

Eligibility criteria.

Inclusion Criteria for TBI Group
  • A documented moderate to severe TBI posttraumatic

    • Amnesia (PTA) > 24 h

    • Loss of consciousness (LOC) >30 min

    • Global cognitive score (GCS) <13, or

    • Intracranial neuroimaging abnormalities (Head CT or MRI)

  • Mild TBI with abnormalities on imaging exam.

  • Ages 18–80 years-old

  • 1 week post injury and admitted to the hospital for TBI.

  • All participants must be fluent in English or Spanish.

Inclusion Criteria for non-TBI Orthopedic Control Group:
  • Abbreviated Injury Score of ≤4 (not life threatening) for extremity and/or pelvis injury and/or rib fracture

  • Without evidence of TBI based on history or head CT

  • 1 week post injury and admitted to the hospital for trauma.

  • All participants must be fluent in English or Spanish.

Exclusion Criteria for the study
  • Significant polytrauma that would interfere with follow-up and outcome assessment.

  • Major debilitating baseline mental health disorders, major debilitating neurological disease, impairing baseline awareness, cognition, or validity of follow-up and outcome assessment.

  • Significant history of pre-existing conditions that would interfere with follow-up and outcome assessment (e.g., end-stage cancers).

  • Patients on psychiatric hold.

  • Prisoners or patients in custody, pregnancy, low likelihood of follow-up (e.g., participants or family indicating low interest, residence in another state or country, homelessness or lack of reliable contacts).

  • Current participant in an interventional trial (e.g., drug, device, behavioral).

  • Penetrating TBI, spinal cord injury with ASIA score of C or worse and contraindications to MRI.