Fig. 4.

Audiological features of subjects with IKZF2 variants. The first ten panels show the pure tone air conduction thresholds in dB HL of 0.25–8 kHz of subjects identified with an IKZF2 variant (c.485A>C p.(His162Pro) in family W16-0482; c.509G>A p.(Cys170Tyr) in family W22-1907; c.434G>T p.(Cys145Phe) in family W22-2757) from whom audiometric data was available. Black lines with circles represent the right ear, black lines with crosses represent the left ear, grey lines and dots represent the age- and gender-specific 95th percentile. The last panel shows the age-related typical audiograms (ARTA), derived from cross-sectional linear regression analysis of the most recent audiograms of individuals identified with IKZF2 variants. Each blue line represents a ten-year age span. dB HL, decibel hearing level; F, female; kHz, kilo Hertz; M, male; y, years