Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 29;15:4433. doi: 10.1038/s41467-024-48654-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Three and five genetic variants selected for rheumatoid arthritis and psoriasis in GenoBoost are shown as illustrative examples, where GenoBoost selected the genetic variants with inferred non-additive genetic dominance effects, and their closest genes (within the 1Mbp window) were not reported in the GWAS catalog. We show the following in the table: phenotype, variant, minor allele frequency (MAF), annotated gene symbol, and predicted consequence of genetic variant, references for the literature reporting the relevance of the closest gene in the phenotype, inferred mode of inheritance. The line plots in the rightmost column represent the log odds ratio (x-axis) of the sample counts of heterozygous and homozygous minor alleles relative to homozygous major alleles. The error bars represent the 95% confidence intervals for Wald’s statistics with n = 215,768 samples. The three dots connected by a line (y-axis) represent the allelic dosage of 0, 1, and 2 from the top to bottom. The color represents the inferred mode of genetic inheritance by GenoBoost. Source data are provided as a Source Data file.