Table 4.
Risk factors associated to hemorrhage.
| Factor | Univariate analysis | Multivariate anlysis | ||
|---|---|---|---|---|
| p | HR (95%CI) | p | HR (95%CI) | |
| Recurrent event analysis using the Prentice Williams and Peterson-Gap time model for risk factors associated with hemorrhage in 155 brainstem CCM | ||||
| Gender female | 0.18 | 1.42 (0.86–2.35) | 0.38 | 1.25 (0.76–2.05) |
| Developemental venous anomaly | 0.35 | 1.32 (0.74–2.35) | ||
| Prior surgery | 0.22 | 1.43 (0.81–2.52) | ||
| SRS | < 0.001 | 0.16 (0.08–0.32) | < 0.001 | 0.17 (0.09–0.34) |
| Cox analysis for factor associated with new hemorrhage after SRS in 180 CCM* | ||||
| Gender female | 0.34 | 1.64 (0.59–4.59) | ||
| Developemental venous anomaly | 0.43 | 1.56 (0.51–4.72) | ||
| Age at SRS > 35 | 0.002 | 0.21 (0.08–0.56) | ||
| Volume > 0.3 cc | 0.36 | 1.61 (0.58–4.50) | ||
| Margin > 13 Gy | 0.044 | 2.57 (1.03–6.45) | ||
| Hemorrhage before SRS | ||||
| 0 | ||||
| 1 hemorrhages before SRS | 0.74 | 0.79 (0.20–3.11) | ||
| ≥ 2 hemorrhages before SRS | 0.35 | 1.87 (0.50–6.98) | ||
CI: Confidence interval, HR: Hazard ratio, Sterotactic radiosurgery.
*No multivariate analysis was performed due to the low number of events.