Table 4.
Univariate and multivariate analysis of FFR iFR/RFR discordance factors.
| Group | Group | ||||
| GFR-L | p-value | GFR-H | p-value | ||
| OR (95% CI) | OR (95% CI) | ||||
| Univariate analysis: Predictors of FFR+ | iFR/RFR- | |||||
| Hypertension (yes vs. no) | 0.68 (0.08–5.86) | 0.7255 | 0.36 (0.15–0.87) | 0.0233 | |
| DM treatment (insulin vs. others) | 0.30 (0.03–2.69) | 0.2819 | 0.20 (0.04–0.94) | 0.0423 | |
| Multivariate analysis: Predictors of FFR+ | iFR/RFR- | |||||
| Hypertension (yes vs. no) | - | - | 0.48 (0.10–2.26) | 0.3541 | |
| DM treatment (insulin vs. others) | - | - | 0.20 (0.04–0.94) | 0.0429 | |
| Univariate analysis: Predictors of FFR- | iFR/RFR + | |||||
| DM treatment (insulin vs. others) | 11.56 (1.32–100.95) | 0.0269 | 2.30 (0.48–11.00) | 0.2973 | |
| post PCI (yes vs. no) | 0.82 (0.34–2.02) | 0.6694 | 4.04 (1.11–14.68) | 0.0343 | |
| COPD (yes vs. no) | 4.67 (1.40–15.57) | 0.0120 | 2.03 (0.42–9.78) | 0.3781 | |
| Multivariate analysis: Predictors of FFR- | iFR/RFR + | |||||
| DM treatment (insulin vs. others) | 12.96 (1.44–116.82) | 0.0224 | - | - | |
| post PCI (yes vs. no) | - | - | 3.93 (1.08–14.34) | 0.0385 | |
| COPD (yes vs. no) | 2.96 (0.23–37.44) | 0.4014 | 1.71 (0.35–8.44) | 0.5093 | |
| Univariate analysis: Predictors of overall FFR - iFR/RFR discordance | |||||
| Age (per year) | 1.01 (0.98–1.05) | 0.4994 | 0.96 (0.93–0.99) | 0.0414 | |
| Hypertension (yes vs. no) | 1.32 (0.28–6.21) | 0.7268 | 0.38 (0.17–0.84) | 0.0164 | |
| COPD (yes vs. no) | 4.05 (1.29–12.68) | 0.0163 | 0.77 (0.21–2.79) | 0.6950 | |
| Multivariate analysis: Predictors of overall FFR - iFR/RFR discordance | |||||
| Age (per year) | 1.01 (0.98–1.06) | 0.4562 | 0.97 (0.94–1.01) | 0.0954 | |
| Hypertension (yes vs. no) | 1.06 (0.22–5.10) | 0.9420 | 0.43 (0.19–0.96) | 0.0409 | |
| COPD (yes vs. no) | 4.11 (1.30–13.04) | 0.0163 | 0.77 (0.21–2.86) | 0.6998 | |
Abbreviations: COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; FFR, fractional flow reserve; (e)GFR, (estimated) glomerular filtration rate; iFR, instantaneous wave-free ratio; OR, odds ratio; PCI, percutaneous coronary intervention; RFR, resting full-cycle ratio; CI, confidence interval; +, positive assessment result; -, negative assessment result; L, indicates the group with an eGFR 70 mL/min/1.73 m2; H, indicates the group with an eGFR 70 mL/min/1.73 m2.