FIGURE 2.

Diversity of exosome cargo and components. Exosomes are bound by a bilayer membrane containing various lipids including ceramides, sphingomyelin, and cholesterol. Peripheral and integral proteins are present in the membrane including tetraspanins, receptors, and major histocompatibility complex proteins. Exosomal cargo is diverse and includes nucleic acids, soluble and cytoskeletal proteins, lipids, metabolites, and amino acids.