Table IV.
Genotypes and clinical characteristics at two single nucleotide polymorphisms of autophagy-related protein 16 like 1 gene.
| rs2241880 | rs4663421 | |||||
|---|---|---|---|---|---|---|
| Variable | AA + AG (n=163) | GG (n=14) | P-value | CC + CG (n=30) | GG (n=147) | P-value |
| ANCA specificity (%) | 0.824 | 0.206 | ||||
| MPO | 102 (77.86) | 10 (76.92) | 16 (69.57) | 96 (79.34) | ||
| PR3 | 15 (11.45) | 1 (7.69) | 2 (8.70) | 14 (11.57) | ||
| None | 14 (10.69) | 2 (15.38) | 5 (21.74) | 11 (9.09) | ||
| Median WBC count, x109/l (IQR) | 8.16 (5.84-10.90) | 8.01 (6.45-10.70) | 0.900 | 7.49 (5.94-11.61) | 8.19 (6.10-10.70) | 0.815 |
| Median 24-h UPR, mg (IQR) | 1,011.90 (352.45-1759.40) | 2116.20 (694.80-4393.00) | 0.024 | 1,369.37 (759.19-2875.45) | 912.10 (371.48-1,786.45) | 0.157 |
| Mean albumin, g/l | 29.99±6.51 | 31.28±8.10 | 0.504 | 28.71±8.11 | 30.37±6.33 | 0.274 |
| Median SCR, µmol/l (IQR) | 259.00 (99.00-486.00) | 317 (141.00-607.00) | 0.378 | 249.00 (68.00-450.00) | 267.00 (110.00-511.00) | 0.597 |
| Median eGFR, ml/min x 1.73 m2 (IQR) | 19.08 (8.46-63.37) | 12.66 (7.79-49.11) | 0.439 | 21.41 (8.96-92.15) | 18.17 (8.03-60.29) | 0.626 |
| Median CRP, mg/l (IQR) | 20.80 (9.10-70.60) | 5.80 (3.14-27.45) | 0.010 | 13.58 (9.69-72.20) | 20.60 (6.67-63.34) | 0.941 |
| Median ESR, mm/h (IQR) | 81.00 (52.00-109.00) | 70.00 (27.50-92.00) | 0.189 | 78.50 (38.50-96.75) | 81.00 (44.50-109.75) | 0.542 |
| Mean BVAS | 16.81±0.39 | 13.50±1.41 | 0.017 | 18.23±4.58 | 16.22±4.56 | 0.060 |
ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase; PR3, proteinase 3; WBC, white blood cell; UPR, urinary protein; SCR, serum creatinine; eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; BVAS, Birmingham Vasculitis Activity Score.