Table 3.

Role of SCFs in regulating hematopoiesis process.

Function	Target	Condition	Reference
• Promote proliferation • Maintain the long-term repopulating ability	Densely populated HSCs	In vitro secretion	Broudy 2 Hasan et al. 51
• Support the survival, proliferation, and differentiation • Enhance production of various blood cell lineages.	HSCs and progenitor cell	Cytokine interaction (EPO, IL-3, GM-CSF, and G-CSF)	Broudy 2 Hasan et al. 51 Molineux et al. 135
• Facilitate Mobilization and migration	HSCs	BM	Shah et al. 119 Kurzrock et al. 136
• Play a anchoring role	HSCs	BM	Kurzrock et al. 136
• Create the specialized microenvironment necessary for HSC self-renewal and differentiation	HSCs	Stromal cells	Broudy 2 Hasan et al. 51 Kurzrock et al. 136
• Enhance the proliferative response • Play a role in early lymphopoiesis and T-cell development	HSCs	Cytokine interaction (IL-7)	Kurzrock et al. 136