Fig 3.

Changes, as compared with the beginning of the study, in expression of genes regulating synthesis of IL-6 (A), matrix metalloproteinase-9 (MMP-9) (B), vascular cell adhesion molecule-1 (VCAM-1) (C), and von Willebrand factor (vWF) (D) in endothelial cells undergoing replicative senescence in the presence of the control serum (Control) or the serum collected from the upper limb (UPL) or lower limb (LOL) obtained before sulodexide treatment (Start) or at the end of the experiment after sulodexide treatment (End).