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Changes, as compared with the beginning of the experiment, in population doubling time (PDT) (A), β-galactosidase (B), expression of p21 gene (C) and p53 gene (D) in endothelial cells undergoing replicative senescence in the presence of the control serum (Control) or the serum collected from the upper limb (UPL) or the lower limb (LOL) obtained before sulodexide treatment (Start) or at the end of the experiment after sulodexide treatment (End).
