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Effect of sulodexide 0.5 lipasemic units/mL (SUL) on secretion of IL-6 (A), matrix metalloproteinase-9 (MMP-9) (B), vascular cell adhesion molecule-1 (VCAM-1) (C), and von Willebrand factor (vWF) (D) in the endothelial cells that are senescent by repeated passages in medium supplemented with the control serum (Control) or with the serum collected at the beginning of the study (before oral sulodexide treatment) from the upper limb (UPL) or the lower limb (LOL).
