Pooled proportions of patients with major bleeding after upper extremity vein thrombosis (UEVT). A, Incidence of bleeding in patients treated with direct oral anticoagulants (DOACs), low-molecular-weight heparin (LMWH), and vitamin K antagonists (VKAs) was 2%, 3%, and 3%, respectively. B, Incidence of bleeding in patients with cancer, patients without cancer, and patients with cancer and central venous catheter (CVC)-related thrombosis was 3%, 1%, and 4%, respectively. CI, Confidence interval.