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. 2024 Oct 29;19:151. doi: 10.1186/s13020-024-01007-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of TSN on renal pathology and tubular injury in DN mice. a HE staining of renal tissue (×400, Scale bar: 20 μm). Red arrows indicate mesangial cell proliferation, mesangial matrix deposition. Black arrows indicate protein casts, vacuolar degeneration, proximal tubule microvilli shedding. b PAS staining of renal tissue (×400, Scale bar: 20 μm). Red arrows indicate glycogen deposition. c Western blot bands and quantitative analysis of KIM-1 and NGAL protein levels in renal tissue. NC: normal control group. DN: diabetic nephropathy control group. LT: TSN low dose group. HT: TSN high dose group. VAL: Valsartan treatment group. Data are shown as means ± standard deviations (n = 3). *** p < 0.001, compared with the NC group; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001, compared with the DN group