Table 3.

lymphocyte subsets.

Category	n	% of total	median PFS (mo)	p (log rank)	% without PD at 12 months	SE	low 95% CI	high 95% CI	median OS (mo)	p (log rank)	SE	low 95% CI		high 95% CI
ALC > 1000 at baseline	130	73	10.8	0.482	35	1.9	7.1	14.6	17.5	0.281	1.7	14.1	20.9
ALC < 1000 at baseline	49	27	6.5		37	4.3	0	15	12.4		2.6	7.4	17.4
ALC > 1000 at 3 months	123	69	15.1	0.005	39	3.3	8.6	21.6	18.3	0.001	1.1	16.2	20.4
ALC < 1000 at 3 months	56	31	5.3		27	2	1.4	9.2	9.8		2.3	5.3	14.3
baseline lymphopenia, persistent at 3 months	36	20	5.3	0.047	31	2.2	1.1	9.6	9.9		3.0	4.1	15.7
no baseline or 3 month lymphopenia	107	60	12.3		37	3.5	5.5	19.2	18		1.5	15.1	20.9
baseline lymphopenia, persistent at 3 months	36	20	5.3	0.081	31	2.2	1.1	9.6	9.9		3.0	4.1	15.7
baseline lymphopenia with recovery at 3 months	12	7			50				22		6.5	9.2	34.8
no lymphopenia at baseline or 3 months	107	60	13	0.024	38	3.1	6.9	19.1	18.3	0.01	1.05	16.2	20.4
no lymphopenia at baseline with lymphopenia at 3 months	20	11	4.3		20	2.1	0.1	8.5	8.3		2.6	3.1	13.5
baseline lymphopenia with recovery at 3 months	12	7	NR	0.48	50				22.0	0.548	6.6	9.1	34.9
no baseline lymphopenia or at 3 months	107	60	13		38	3.1	6.9	19.1	18.3		1.1	16.2	20.4
lymphopenia at baseline and at 3 months	36	20	5.3	0.708	31	2.2	1.1	9.6	9.9	0.72	3.0	4.1	15.7
no baseline lymphopenia with lymphopenia at 3 months	20	11	4.3		20	2.1	0.1	8.5	8.3		2.6	3.1	13.5

Table of estimates of median survival by Kaplan–Meier method and percentage without progression at 12 months for leukocyte subsets.

ALC absolute lymphocyte count, PFS progression-free survival, OS overall survival, SE standard error, CI confidence interval.