Table 1.
Data extraction and study characteristics of selected articles: molecular classes analyzed in bacterial biofilms, sorted by an imaging technique.
| Author, year | Imaging modality | Molecular class imaged |
|---|---|---|
| MSI [15] | ||
| Davies et al. (2017) | SIMS | Quorum-sensing molecules |
| Dunham et al. (2018) | SIMS | Quorum-sensing molecules |
| Ding et al. (2016) | SIMS (liquid) | Quorum-sensing molecules, fatty acids, lipids, carbohydrates |
| Hua et al. (2014) | SIMS (liquid) | Fatty acids |
| Hua et al. (2015) | SIMS (liquid) | Fatty acids |
| Zhou et al. (2016) | SIMS (liquid) | Molecular fragments (non-specified) |
| Blaze et al. (2012) | MALDI | Proteins, peptides |
| Brockmann et al. (2019) | MALDI-2 | Quorum-sensing molecules, metabolites |
| Brockmann et al. (2021) | IR-MALDI-2 | Quorum-sensing molecules, lipids |
| Lukowski et al. (2021) | MetA-LDI | Proteins, peptides, lipids |
| Kurczy et al. (2015) | NIMS | Molecular fragments (non-specified) |
| Louie et al. (2013) | NIMS | Metabolites |
| Cui et al. (2013) | Fs-LDPI-MS | Metabolites |
| Zhang et al. (2020) | Cryo-OrbiSIMS | Lipids, quorum-sensing molecules, nucleobases, metabolites |
| Watrous et al. (2013) | nanoDESI | Proteins, peptides, lipids, fatty acids |
| Spectroscopy [7] | ||
| Bodelón et al. (2016) | SERS | Metabolites |
| Polisetti et al. (2017) | SERS | Metabolites |
| Do et al. (2019) | SERS | Metabolites |
| Baig et al. (2016) | SERS | Metabolites, quorum-sensing molecules |
| Ivleva et al. (2010) | SERS | Metabolites, proteins, carbohydrates |
| Garg et al. (2022) | SERS | Proteins, carbohydrates, DNA |
| Holman et al. (2009) | SR-FTIR | Proteins, carbohydrates, DNA |
| Fluorescence imaging [4] | ||
| Berk et al. (2012) | CLSM | Proteins, carbohydrates |
| Decker et al. (2015) | CLSM | Proteins |
| Narasimhan et al. (2017) | CLSM | Carbohydrates |
| El-Kirat-Chatel et al. (2014) | Fluorescence microscopy | Proteins |
| NMR [1] | ||
| Simkins et al. (2018) | NMR | Oxygen |
| µCT [1] | ||
| Keren-Paz et al. (2018) | µCT | Calcium carbonate |
| Multimodal [5] | ||
| Lanni et al. (2014) | SIMS, MALDI | Metabolites, quorum-sensing molecules |
| Lanni et al. (2014) | SIMS, CRM | Quorum-sensing molecules, proteins, carbohydrates |
| Baig et al. (2015) | SIMS, CRM | Quorum-sensing molecules |
| Dunham et al. (2016) | SIMS, MetA-SIMS, MetA-LDI | Quorum-sensing molecules |
| Si et al. (2016) | MALDI, fluorescence microscopy | Metabolites |