Table 2.
Correlation of T cell and macrophage subtypes with tumor characteristics and status of preoperative chemotherapy.
Cell phenotype, Median (range) n/mm2 | CLM size | P | Preoperative chemotherapy | P | Primary location | P | Node positive tumor | P | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
≤3 cm | 3 cm | Yes | No | Right | Left | Yes | No | |||||
Total CD68+ | 48 (2–237) | 44 (12–276) | 0.83 | 37 (2–181) | 63 (14–273) | 0.002 | 63 (11–273) | 40 (2–236) | 0.07 | 43 (2–273) | 48 (7–236) | 0.33 |
CD68+CD163+ (M2) | 0 (0–36) | 2 (0–97) | 0.01a | 2 (0–97) | 0 (0–36) | 0.03 | 1 (0–97) | 1 (0–23) | 0.72 | 1 (0–97) | 1 (0–36) | 0.94 |
CD68+TGFβ+ | 1 (0–29) | 1 (0–17) | 0.57 | 1 (0–21) | 2 (0–29) | 0.02 | 3 (0–29) | 1 (0–21) | 0.04 | 1 (0–29) | 1 (0–17) | 0.73 |
CD3+FOXP3+ | 0 (0–16) | 1 (0–3) | 0.97 | 0 (0–2) | 1 (0–16) | 0.001 | 1 (0–2) | 0 (0–16) | 0.24 | 0 (0–16) | 1 (0–3) | 0.08 |
CD3+CD4+ | 3 (0–259) | 2 (0–58) | 0.66 | 2 (0–259) | 3 (0–145) | 0.49 | 1 (0–58) | 4 (0–259) | 0.02 | 3 (0–259) | 2 (0–259) | 0.88 |
CD3+CD8+ | 1 (0–49) | 1 (0–26) | 0.97 | 1 (0–49 | 1 (0–49) | 0.17 | 1 (0–28) | 2 (0–49) | 0.03 | 1 (0–5) | 1 (0–49) | 0.69 |
CD3+CD8+pSMADd3+ | 0 (0–1) | 0 (0–2) | 0.47 | 0 (0–2) | 0 (0–10) | 0.15 | 0 (0–2) | 0 (0–10) | 0.44 | 0 (0–10) | 0 (0–5) | 0.02 |
CD3+CD4+pSMADd3+ | 0 (0–3) | 0 (0–3) | 0.41 | 0 (0–1) | 0 (0–5) | 0.002 | 0 (0–2) | 0 (0–5) | 0.45 | 0 (0–5) | 0 (0–2) | 0.16 |
Statistically significant p-values are in bold.