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. 2023 Jun 22;1:1. doi: 10.1038/s44276-023-00002-0

Table 3.

Previously suggested pedigree symbols for TGD patients.

Transgender man (assigned female at birth) Transgender woman (assigned male at birth) Non-binary or other gender-diverse identities (assigned female at birth) Non-binary or other gender-diverse identities (assigned male at birth)
Bennett et al. [8] graphic file with name 44276_2023_2_Taba_HTML.gif graphic file with name 44276_2023_2_Tabb_HTML.gif graphic file with name 44276_2023_2_Tabc_HTML.gif graphic file with name 44276_2023_2_Tabd_HTML.gif
 Comments

Recommend symbol representing “phenotypic gender”, which is ambiguous

Assuming sex chromosomes may be inaccurate and cause clinician discomfort [9, 10]

Provenzale et al. [11] graphic file with name 44276_2023_2_Tabe_HTML.gif graphic file with name 44276_2023_2_Tabf_HTML.gif
 Comments

Denoting sex assigned at birth in the centre could be interpreted as considering that this is core to the patient’s identity

Symbols could easily be misdrawn/misinterpreted

Barnes et al. [7] graphic file with name 44276_2023_2_Tabg_HTML.gif graphic file with name 44276_2023_2_Tabh_HTML.gif graphic file with name 44276_2023_2_Tabi_HTML.gif graphic file with name 44276_2023_2_Tabj_HTML.gif
 Comments

Use symbol that aligns to patient’s gender

Annotation to indicate sex assigned at birth is preferable to sex chromosomes

Participants indicated that diamond shape did not seem validating, as it is frequently used when gender is not known

Recommendations supported by Bennett et al. [12]

Tuite et al. [13] graphic file with name 44276_2023_2_Tabk_HTML.gif graphic file with name 44276_2023_2_Tabl_HTML.gif graphic file with name 44276_2023_2_Tabm_HTML.gif graphic file with name 44276_2023_2_Tabn_HTML.gif
 Comments

“Superscript symbols” eliminate the need for annotation

Deviation from standardised pedigree and astrological symbols may cause confusion

Triangle could be confused for “pregnancy not carried to term”

von Vaupel-Klein & Walsh [1] graphic file with name 44276_2023_2_Tabo_HTML.gif graphic file with name 44276_2023_2_Tabp_HTML.gif graphic file with name 44276_2023_2_Tabq_HTML.gif graphic file with name 44276_2023_2_Tabr_HTML.gif
 Comments Incorporate Barnes et al. [7] recommendations and suggest alternative for non-binary individuals with less potential for confusion and feeling of gender identity being invalidated