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Comparison of the Z-score distribution between linear and b-spline models for the ROIs that were significant for MD for the linear model but not for the b-spline model. Notably, for the 16pDel group, the mode of the Z-scores for the linear model (mode = 1.05) is substantially higher than for the b-spline model (mode = 0.27), consistent with the notion that it is a poor fit for the data (high bias, as well as high variance).
