Fig. 2. Caspase-2, caspase-9, or combined loss of effector caspase-3/caspase-7 protects Nalm6 cells from cytokinesis failure–induced cell death, but caspase-8 does not.

(A) Representative dot plots of annexin V/PI–stained Nalm6 WT cells or derivative KO clones after 48 hours of treatment with 2 μM ZM (or untreated controls). (B) Quantification of (A). Bar charts represent the means ± SD of the percentage of events in each staining condition. N ≥ 3 independent biological replicates. Statistical significance was calculated by unpaired t test on the percentage of live cells of each KO derivative clone compared to WT cells. ****P < 0.0001.