Table 1.

Early signs of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia as reported by patients, care partners and healthcare professionals.

Symptom category	Symptoms as reported by patients and care partners	Symptoms as reported by healthcare professionals
Cognitive impairment	Problems in the workplace  “My coworker told me she thought I had MS”  “My brother was asking me for advice on how to do his job” Forgetfulness  “[…] being forgetful on the job”  “Then aggression came along, […] not being able to remember causes that (i.e., aggression)” Impaired comprehension  “She was starting to put things up [on social media] that just didn't make sense”	Problems in the workplace  “It's when people start often making mistakes in their job, that's when people know that something is seriously wrong” Impaired decision-making
Behavioral and psychiatric	Apathy  “She just wasn't engaged anymore” Aggression Depression and/or anxiety  “Early on, we could say it's not the disease: it's the stress of work, it's the stress of being a mom, raising children, financial stress” Impaired/out-of-character decision-making	Depression and/or anxiety  “[Regarding mood changes] It was clear that what she was presenting was completely disproportionate to […] menopause”
Motor	Impaired mobility  “I noticed this extreme slowing down, they couldn't pick up the pace”  “My coworker told me she thought I had MS” Shuffling gait  “Why is nanny walking like a penguin?”	Gait apraxia  “I remember some patients saying, “I don't know how to walk anymore’” Incoordination of upper and lower limbs
Speech difficulty	Difficulty breathing and speaking	Speech disturbance/difficulty with words
Other	Loss of vision	—

MS: Multiple sclerosis.